Abstract: To discuss and summarize the clinical features and treatment methods for eosinophilic granuloma of the bone. Methods: The data of 25 patients with localized eosinophilic granuloma of bone, treated from July 1998 to May 2005, were retrospectively investigated. Twenty- four cases had solitary symptomatic lesions and one case had multiple lesions on the spine. Results: The mean follow- up period was 33 months. No recurrence was found in any patient and all survived the disease. Conclusion: The physical manifestations of eosinophilic granuloma of bone are varied. Some cases may have a distinctive manifestation and are therefore easier to diagnose. Surgery is currently an effective means of treatment. Lesion curettage and bone graft or bone cement padding can be used effectively for most patients. Chemoradiotherapy can be used to control multiple lesions or recurrent lesions.