反义ODN对人卵巢癌细胞株A2780 FSHR表达的影响

沈娅, 朱长虹, 甄波, 刘子龙

沈娅, 朱长虹, 甄波, 刘子龙. 反义ODN对人卵巢癌细胞株A2780 FSHR表达的影响[J]. 中国肿瘤临床, 2007, 34(5): 290-292.
引用本文: 沈娅, 朱长虹, 甄波, 刘子龙. 反义ODN对人卵巢癌细胞株A2780 FSHR表达的影响[J]. 中国肿瘤临床, 2007, 34(5): 290-292.

反义ODN对人卵巢癌细胞株A2780 FSHR表达的影响

详细信息
    通讯作者:

    刘子龙,Email: liuzilong04@126.com

  • 中图分类号: R737.31

  • 摘要: 卵巢癌占妇科恶性肿瘤死亡率首位,常规治疗方法为手术和化疗,但生存率较低。大量研究显示,卵泡刺激素(Follicle stimulating hormone,FSH)对卵巢癌的发生发展具有明显促进作用[1]。FSH生理作用的发挥是通过特异性G蛋白偶联受体(Folliclestimulating hormone receptor,FSHR)所介导。近年,FSHR在卵巢中的表达倍受关注。卵巢癌细胞有无FSHR过度表达,恶性与良性肿瘤细胞间FSHR表达差异等问题,目前尚不清楚。
  • [1] 1 Kraemer S, Jaeger WH, Lang N. Growth regulation effects of gonadotropin induced steroidogenic response in human ovarian cancer[J]. Anticancer Res, 2001, 21(3B): 2005~2010
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    6 Albanese C, Christin- Maitre S, Sluss PM, et al. Development of a bioassay for FSH using a recombinant human FSH receptor and a cAMP responsive luciferase reporter gene[J]. Mol Cell Endocrinol, 1994, 101(1~2): 211~219
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    8 Nakano R, Kitayama S, Yamoto M,et al. Localization of gonadotropin binding sites in human ovarian neoplasms [J]. Am J Obstet Gynecol, 1989, 161(4): 905~910
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出版历程
  • 收稿日期:  2006-12-28
  • 发布日期:  2007-03-14

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