Abstract: Objective: To evaluate the application and clinical effect of GI tract reconstruction with jejunal interposition in various surgical operations. Methods: Data of 202 cases undergoing the GI tract reconstruction with jejunal interposition, during a period from January 1991 to August 2005, were retrospectively analyzed. The cases included functional reconstruction, P- type reconstruction, bile duct drainage, modified reconstruction, reconstruction after proximal subtotal gastrectomy, etc. Results: All patients were undergone the GI tract reconstruction with jejunal interposition. No dumping stomach, reflux esophagitis and apparent anastomosis leakage have been observed. Conclusion: In a conclusion,jejunal interposition is simple to operate, easy to master and the effect of clinical application is satisfactory.