Abstract: Objective: To investigate the expression of vascular endothelial growth factor C (VEGFC), matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase 1 (TIMP1) in cervical cancer tissue and the relationship between these levels and the clinicopathologic characteristics of cervical carcinoma. Methods: The expression of VEGFC, MMP9 and TIMP1 in 62 patients with cervical carcinoma of stage- Ⅰ and Ⅱ were determined using immunohistochemistry (SP method) and statistical analysis was then conducted. Results: There were high expression rates for VEGFC (77.4%), MMP9(69.4%), and TIMP1(62.9%) in the cases of squamous cancer (stage- Ⅰand Ⅱ). The expression rate of VEGFC in the stage- Ⅰ and Ⅱ cases and in the cases with lymph node metastasis was 73.8%, 85% and 100.0%, respectively, while that of MMP9 was 66.7%, 75% and 93.3% and that of TIMP1 was 64.3%, 60% and 66.7%, respectively. The expression of VEGFC, MMP9 and TIMP1 was higher as the depth of stromal infiltration by the cervical carcinoma was equal to or more than 1/2, compared to that of tumors with an infiltration depth of less than 1/2 (P<0.05). There was a correlation between the expression rates and the depth of infiltration as well as lymphatic metastasis. Conclusions: Our research indicates that there is a close correlation between expression of VEGFC, MMP9 and TIMP1 and tumor cell invasion and metastasis. VEGFC, MMP9 and TIMP1 may play important roles in the development and aggressiveness of human cervical carcinoma.