细胞增殖与凋亡相关因子在大小肝癌中的表达差异及其意义探讨

Biological effects of Ki67, Fas, Bax, and survivin in SHCC and HCC

    摘要
  • 摘要: 目的:检测Ki67、Fas、Bax及Survivin蛋白在人体大、小肝癌组织中的表达及其与肝癌生物学行为的关系。方法:应用免疫组化方法检测40例小肝癌和43例大肝癌中Ki67、Fas、Bax及Survivin蛋白的表达,结合临床病理资料分析。结果:Fas及Bax在小肝癌中的表达显著高于大肝癌(P<0.05);Survivin与Ki67的表达均与Fas表达呈显著负相关(P<0.05),与包膜侵犯、癌栓形成及肿瘤转移呈显著正相关(P<0.01);Fas的表达与癌栓形成及肿瘤转移呈显著负相关(P<0.01)。结论:伴随Fas及Bax的表达减少或缺失,肝癌细胞凋亡的趋势逐渐减弱,从而导致肿瘤迅速生长、增大。Ki67、Fas与Survivin的表达与肝癌的生物学行为密切相关。

     

    Abstract: Objective: Our study will try to detect the different expression patterns of Ki67, Fas,Bax and survivin in SHCC and advanced HCC and to study the relationships with biological behavior.Methods: The expression of Ki67, Fas, Bax and survivin protein in 40 cases of SHCC and 43 cases of HCC was detected by immunohistochemistry and was analyzed in conjunction with clinicopathological factors. Results: The expression of Fas and Bax in SHCC is more pronounced than it is in HCC (P<0.05). The expression of survivin and Ki67 both have a negative correlation with Fas expression(P<0.05)and a positive correlation with envelope invasion, embolus formation and tumor metastasis(P<0.01). The expression of Fas has a negative correlation with embolus formation and tumor metastasis (P<0.01).Conclusions: Advanced HCC shows a low level of apoptosis and diminished or completely absent expression of Fas and Bax, features that help ensure rapid tumor growth. The expression of Ki67, Fas and Survivin may play an important role in the biological behavior of SHCC and HCC

     

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