Abstract: Objective: To explore clinical and pathological characteristics of large intestinal cancer with thrombocytosis. Methods: The data of clinical and pathologic characteristics of 383 patients with large intestinal cancer were retrospectively analyzed, among which thrombocytosis was seen in 103 cases. Results: The large intestinal cancer patients with an increased platelet count composed 26.9% of the cases (103/383). There was no correlation between the increased platelet count and the sex, age or diseased region of the patients, but there was a correlation between thrombocytosis and the condition of the intestinal obstruction (P<0.0005). There was also a correlation between thrombocytosis and the tumor's macroscopic shape, diameter, degree of differentiation, histological grade and pathological stage,infiltrative depth of the intestinal wall and lymphatic metastasis. Conclusion: Increased platelet count is common in patients with advanced stage large intestinal cancer with a poor prognosis.