Abstract: Objective: To summarize and analyze the clinical characteristics, treatment outcome,overall survival rates and prognosis of peripheral T-cell lymphoma (PTCL) patients. Methods: Data from 96 patients with PTCL were analyzed retrospectively. Results: Histopathological subgroups included 66 PTCL-unspecified (PTCL-U) cases, 6 anaplastic large cell lymphoma (ALCL) cases, 17 angiocentric lymphoma (NK/T-cell lymphoma, NK/TCL) cases, 5 intestinal T-cell lymphoma cases and 2 angioimmunoblastic T -cell lymphoma cases. Most of the patients were treated with combined chemotherapy (CHOP regimen). Overall response rate was 88.8% with 57.3% complete remission (CR)rates for 89 evaluable patients. The median survival time (MST) was 31.9 months. The 1-, 3-, and 5-year overall survival (OS) rates were 83.3%, 42.7% and 35.1%, respectively. Multivariate analysis showed that IPI score was an independent prognostic factor for PTCL (P<0.05). Conclusion: Althoughconventional chemotherapy yields high response rates for PTCL, the long-term survival is still poor.Further investigation for optional treatment is needed.