Abstract: Objective: To investigate the clinical features of primary central nervous system lym-phoma(PCNSL), evaluate the efficacy of high-dose methotrexate(MTX)-based chemotherapy combining with whole brain radiation therapy (WBRT) for immunocompetent Chinese patients with PCNSL.Method: Clinical data of 34 patients that were pathologically diagnosed with PCNSL was analyzed ret-rospectively, and Kaplan-Meier method was used to calculate survival time. Result: Among 34 PCNSL patients, 31 (91.2%) were diagnosed with B-cell lymphoma, 3 (8.8%) T-cell lymphoma. The complete remission rate of treatment was 41.2%, and the 2-year survival rate was 60.2%. The overall survivaltime showed statistic correlation with tumor pathological type and the type of treatment patient received.Conclusion: The major clinical symptom of PCNSL is intracranial hypertension and it is considered asan important factor that affects the disease progression and prognosis. B- cell lymphoma is the predomi-nant subtype of PCNSL and combination of High-dose MTX-based chemotherapy with whole brain irra-diation treatment is a more efficient approach.