Mannatide Combined with Vinorelbine and Capecitabine for Treating Advanced Breast Cancer
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摘要: 目的:观察力尔凡联合长春瑞滨、卡培他滨方案治疗晚期乳腺癌的疗效及安全性。方法:39例有可测量病灶的转移性乳腺癌患者,按就诊先后顺序随机分为综合治疗组和对照组。对照组患者中心静脉持续滴注长春瑞滨,口服卡培他滨。综合治疗组在对照组用药的基础上加用力尔凡静脉滴注。结果:综合治疗组21例患者中CR2例(9.5%),PR6例(28.6%),MR4例(19.1%),总有效率为58.2%。对照组18例患者中,CR1例(5.6%),PR4例(22.2%),MR3例(16.6%),总有效率为44.4%。综合治疗组的有效率明显高于对照组,且不良反应的发生率低于对照组。结论:力尔凡联合长春瑞滨、卡培他滨治疗晚期乳腺癌,可以起到增效减毒作用,并且使长春瑞滨、卡培他滨作为二线方案治疗晚期乳腺癌,不良反应可以耐受。Abstract: Objective: To observe the curative effect and safety of mannatide combined with vi-norelbine and capecitabine on advanced breast cancer. Methods: 39 patients with metastatic advanced breast cancer were randomly divided into two groups. Control group(n=18) received vinorelbine 6mg/m/d,d1-5 civ,cycles were repeated every 21 days,also received capecitabine for 2-4 cycles at the sametime. In addition to the same regimen, treating group(n=21) accepted intravenous infusion of mannatide(10mg/d)for the first 3 days, then increased to the dose of 20mg/d for 8-12weeks. Results: In treatment and control groups, the effective rates were 58.2% and 44.4%(P<0.05), the rates of side effects in treat-ment group were less than in control group. Conclusions: Mannatide combined with vinorelbine andcapecitabine is effective for advanced breast cancer and can reduce the side effects of vinorelbine plus capecitabine.
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Keywords:
- Advanced breast cancer /
- Mannatide /
- Vinorelbine /
- Capecitabine
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