Comparison between the Effects of Paclitaxel and Oxaliplatin Combined with 5-Fluorouracil/Folinic Acid in the Treatment of Advanced Gastric Cancer
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摘要: 目的 :观察并比较紫杉醇联合氟脲嘧啶/亚叶酸(5-FU/CF)与草酸铂联合5-FU/CF治疗晚期胃癌的疗效及毒副反应。 方法 :随机将晚期胃癌患者分为两组:紫杉醇联合5-FU/CF组(A组)27例,草酸铂联合5-FU/CF(B组)29例。每例患者至少完成2周期以上的化疗。 结果 :A组有效率(CR+PR)为59.26%,中位缓解期5.8个月,中位生存期11.6个月。B组有效率(CR+PR)为55.17%,中位缓解期6.2个月,中位生存期10.8个月。两组的主要毒副反应为骨髓抑制、神经毒性和消化道反应。两者相比A组的骨髓抑制、脱发较重,B组轻度腹泻的发生率稍高。 结论 :紫杉醇联合5-FU/CF与草酸铂联合5-FU/CF两方案治疗晚期胃癌疗效相当,毒副反应均可耐受。Abstract: Objective :To observe and compare the therapeutic efficacy and adverse side effects ofpaclitaxel and oxaliplatin (L-OHP) combined with 5-fluorouracil/leucovorin (5-FU/CF) in the treatmentof patients with advanced gastric cancer (AGC). Methods :A total of 56 patients with AGC were ran-domized into two groups. Two or more cycles of chemotherapy were completed. Group A consisted of 27patients who received paclitaxel plus 5-FU/CF and group B consisted of 29 patients who received ox-aliplatin plus 5-FU/CF. Results :In group A and B, the response rate (CR +PR) was 59.26% and55.17%, the median duration of the therapeutic effects was 5.8 and 6.2 months, and the median sur-vival of patients was 11.6 and 10.8 months, respectively. The most common side effects in both groupswere myelosuppression, mild neuro-sensory toxicity and sensitivity of the gastrointestinal tract. Com-pared with patients in group A, patients in group B experienced milder myelosuppression and more se-rious diarrhea. Conclusion :The effects of paclitaxel or L-OHP combined with 5-FU/CF are compara-ble. The adverse side effects are mild and patients tolerate the chemotherapy well.
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Keywords:
- Gastric cancer /
- Combined chemotherapy /
- Paclitaxel /
- Oxaliplatin
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