头颈部滑膜肉瘤的治疗及预后分析
Treatment and Prognostic Variables of Synovial Sarcoma in the Head and Neck
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摘要: 目的:探讨头颈部滑膜肉瘤的临床诊断和治疗方法,分析头颈部滑膜肉瘤的预后不良因素,为治疗该肿瘤提供借鉴。方法:回顾性分析1984年5月~2006年12月本院收治的8例头颈部滑膜肉瘤病例,单纯手术治疗5例,单纯放射治疗1例,手术加放射治疗1例,未治疗1例。复习国内外相同疾病文献36例。通过对所有患者病历资料的研究,得出头颈部滑膜肉瘤的诊断、治疗经验,并从中分析出影响头颈部滑膜肉瘤预后的因素。结果:头颈部滑膜肉瘤临床表现无特异性,鉴别诊断困难。头颈部滑膜肉瘤组织来源不清,明确诊断需病理学检查。肿瘤呈浸润性生长,手术切除安全范围及放射治疗野皆难以确定,治疗后经常复发,复发后的肿瘤恶性程度增加,并且远处转移机会增大,导致治疗失败。头颈部神经血管密集,造成广泛切除的局限性是影响预后的主要因素。头颈部滑膜肉瘤5年生存率小于20%,目前综合治疗是提高生存率的有效方法。结论:头颈部滑膜肉瘤目前无特殊的诊断方法,诊断需有经验的病理科医师配合免疫组织化学。单纯手术易复发,单纯放射治疗效果差,目前仍无有效的化疗方案。该病死亡率高,传统的扩大切除术配合放射治疗是目前唯一可行的治疗方法。Abstract: Objective: To analyze the treatment methods and prognostic variables of synovial sarcoma in the head and neck. Methods: Data from 8 cases with synovial sarcoma in the head and neck treated in The Affiliated Tumor Hospital of Harbin Medical University from May 1975 to December 2006 were analyzed. Five patients underwent simple surgery, 1 patient received radiotherapy alone, 1 patient received surgery plus radiotherapy, and 1 patient received no therapy. Thirty-six similar cases abroad were also reviewed. Results: The clinical manifestations of synovial sarcoma in the head and neck were not specific. The treatments failed because of unclear origins of infiltrative growth and the difficulty in identifying the tumor margin and extent of radiation therapy. The abundant nerves and vessels in the head and neck were the major factors impacting prognosis. The overall 5-year survival rate was less than 20%. Conclusion: There was no specific method to diagnose synovial sarcoma in the head and neck. Immunohistochemistry is helpful. At present, there are no effective chemotherapeutics. The recurrence rate after simple surgery or radiotherapy alone is high. Standard surgery combined with radiotherapy is the most effective treatment and can increase patients' survival rate over either treatment alone.