Abstract: Objective: To observe the clinical outcome of Biafine cream in preventing acute irradiation-induced dermal injury in combined chemoradiation for the treatment of nasopharyngeal carcinoma. Methods: Fifty-one patients who underwent radiotherapy and chemotherapy were randomized into two groups. The treatment group(25 cases) was given Biafine cream application starting with the first radiotherapy and chemotherapy session and the control group (26 cases) did not receive this medication. Results: Dermal toxic rate and the degree to which it occurred in the treatment group were significantly lower than those in the control group. Conclusion: Biafine cream can effectively prevent acute irradiation-induced dermal injury. It alleviates the patients' sufferings, improves their quality of life, and ensures an uneventful radiotherapy.