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摘要: 组织驻留记忆 T 细胞（ tissue-resident memory T cells，TRMs）作为一种特殊的记忆T细胞，在免疫应答中发挥着极其重要的作用。其特征是可表达归巢受体，从而具备驻留特性，因此能够驻留在外周组织器官中，当病原体侵袭时可以迅速反应。目前，TRMs（尤其是CD8+TRMs）与肿瘤的关系及其在抗肿瘤中的应用被愈加重视，一方面是CD8+TRMs可以通过分泌颗粒酶B、穿孔素和INF-γ等因子直接杀伤肿瘤细胞，另一方面一些抗肿瘤措施（如放化疗、免疫治疗等）可以使CD8+TRMs在肿瘤组织中富集，从而进一步提高治疗的效果。本文就CD8+TRMs的亚群分类、在肿瘤中如何调控形成以及其在肿瘤治疗中的作用等方面的研究进展进行综述。Abstract: Tissue-resident memory T cells (TRMs) are a special type of memory T cells that play an important role in the immune response. They are characterized by the expression of homing receptors, which imparts them resident properties to ensure that they can reside in peripheral tissues and organs, and thus, respond rapidly to invading pathogens. There is increasing research attention on the relationship between TRMs (especially CD8+TRMs) and their anti-tumor applications. On the one hand, CD8+TRMs directly kill tumor cells by secreting certain cytokines, such as granase B, perforin, and INF-γ. On the other hand, some anti-tumor treatments (such as radiotherapy, chemotherapy, and immunotherapy) enrich CD8+TRMs in tumor tissues, which can further improve their therapeutic effect. Here, we review research progress on the classification of CD8+TRMs, their regulatory mechanism in tumors, and their applications in cancer therapy.
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Key words:
- tissue residence /
- CD8+T cells /
- regulation mechanism /
- tumor /
- immunotherapy
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