Objective  To comprehensively analyze the results of opportunistic screening for upper gastrointestinal cancer in Zhejiang Province from 2019 to 2021, and to provide guidance for the development of opportunistic screening, early detection and treatment of upper GI cancer.

  Methods  The data of opportunistic screening of upper GI cancer in Zhejiang Province from 2019 to 2021 were derived from the national project data management platform; the biopsy rate; the detection rate of neoplastic lesions; and the calculated early diagnosis rate of upper GI cancer. The differences of the rates between the different groups were compared by χ² tests and trend χ² test.

  Results  A total of 247, 055 patients were included in opportunistic screening for upper GI cancer in 2019-2021, of which 233, 624 were biopsy histopathological examinations. It was found that the detection rate of upper GI neoplastic lesions increases with age (P<0.001) and is significantly higher in men than in women (P<0.001). In the comparison of detection rates, the detection rate of tumor lesions of upper GI cancer in the painless gastroscopy group was lower than that of the non-painless gastroscopy group, while the detection rate of tumor lesions of upper GI cancer in the staining group was higher than that of the non-stained group. The detection rate of tumor lesions of upper GI cancer in the HP-positive group was higher than that in the HP-negative group ( P<0.001).

  Conclusions  The results of this study confirmed that the coverage of upper GI cancer screening and early diagnosis and treatment can be expanded according to the national implementation plan, which is of great significance in improving the detection rate of upper GI cancer. However, it is still necessary to further improve the awareness rate of cancer knowledge and the early diagnosis rate of upper GI cancer in the population.