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摘要: 神经母细胞瘤(neuroblastoma,NB)是儿童最常见的颅内实体肿瘤,发现时常常已是晚期,易发生转移,高危NB患儿即使接受高强度治疗,仍可出现复发或转移,治疗效果差。目前NB的发病机制及治疗等已成为儿童实体恶性肿瘤研究的热点、难点。近年来,随着单细胞测序等各种技术手段的进步,NB的发病机制、治疗手段等相关研究取得了诸多进展。本文将对近年来NB的研究进展进行文献综述,阐述了NB的起源、分子遗传学调控机制及免疫学调控机制研究成果,并介绍NB单克隆抗体、肿瘤疫苗、过继细胞疗法及小分子抑制剂的最新进展。Abstract: Neuroblastoma is the most common intracranial solid tumor in children. It is often found at an advanced stage and is prone to metastasis. Even when high-risk patients receive high-intensity treatment, it can still recur or metastasize, and the prognosis is poor. Currently, the pathogenesis and treatment of neuroblastoma have become a research focus and are recognized as difficult issues in the study of pediatric solid tumors. In recent years, with the progress of single-cell sequencing and other techniques, many advances have been made in research on the pathogenesis and management of neuroblastoma. This article reviews the recent progress of research on neuroblastoma, including its origin and molecular, genetic, and immunological regulation mechanisms, and discusses the latest advances in research on monoclonal antibodies, tumor vaccines, adoptive cell therapy, and small-molecule inhibitors of neuroblastoma.
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Key words:
- neuroblastoma /
- pathogenesis /
- immunotherapy /
- targeted therapy /
- research front
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