赵海远, 刘刚, 李阳, 刘奔, 杨万超, 赵军. 体脂率作为预测胃癌手术后并发症和生存率新指标的研究探讨[J]. 中国肿瘤临床, 2023, 50(16): 821-828. DOI: 10.12354/j.issn.1000-8179.2023.20230536
引用本文: 赵海远, 刘刚, 李阳, 刘奔, 杨万超, 赵军. 体脂率作为预测胃癌手术后并发症和生存率新指标的研究探讨[J]. 中国肿瘤临床, 2023, 50(16): 821-828. DOI: 10.12354/j.issn.1000-8179.2023.20230536
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Haiyuan Zhao, Gang Liu, Yang Li, Ben Liu, Wanchao Yang, Jun Zhao. Body fat ratio as a new predictor of complications and survival after gastric cancer surgery[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(16): 821-828. DOI: 10.12354/j.issn.1000-8179.2023.20230536
Citation: Haiyuan Zhao, Gang Liu, Yang Li, Ben Liu, Wanchao Yang, Jun Zhao. Body fat ratio as a new predictor of complications and survival after gastric cancer surgery[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(16): 821-828. DOI: 10.12354/j.issn.1000-8179.2023.20230536
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体脂率作为预测胃癌手术后并发症和生存率新指标的研究探讨

Body fat ratio as a new predictor of complications and survival after gastric cancer surgery

    摘要
  • 摘要:
      目的  探究体脂率（body fat ratio，BFR）、内脏脂肪面积（visceral fat area，VFA）、体质指数（body mass index，BMI）和内脏脂肪密度（visceral fat density，VFD）之间的关系，并评估其在胃癌患者术后并发症风险和生存状态评估中的可靠性。
      方法  前瞻性选取2017年6月至2019年7月期间在皖南医学院第一附属医院接受胃癌手术治疗的402例患者。测量BFR、VFA、BMI和VFD，并记录基本资料、临床数据、并发症和生存状况。统计分析得到BFR最佳界值，以此分组并比较差异。
      结果  BFR与VFA和BMI呈正相关（R=0.784、R=0.731），与VFD呈负相关（R=−0.814），具有显著相关性（P<0.05）。BFR、VFA、BMI和VFD在胃癌术后并发症的诊断中受试者工作特征（receiver operating characteristic curve，ROC）曲线下面积（area under curve，AUC）值均>0.7，BFR最佳截断（cut-off）值为28.95。BFR-Low组术后并发症较少，术中指标、住院时间和费用较低（P<0.05）。通过多种模型验证，发现BFR对于预测并发症具有高度的诊断意义。BFR-High组具有更好的生存期（P<0.05）。
      结论  BFR与BMI、VFA和VFD密切相关。合理控制体脂率或适度增加可能有助于预防和管理胃癌手术后并发症，并提高患者的远期生存期。

     

    Abstract:
      Objective  To explore the relationship between body fat ratio (BFR), visceral fat area (VFA), body mass index (BMI), and visceral fat density (VFD) and assess their reliability in evaluating the risk of postoperative complications and survival status in patients with gastric cancer.
      Methods  We conducted a prospective study of 402 patients who underwent gastric cancer surgery at The First Affiliated Hospital of Wannan Medical College from June 2017 to July 2019. BFR, VFA, BMI, and VFD were measured, and baseline data, clinical information, complications, and survival status were recorded. Statistical analysis was performed to determine the optimal BFR threshold and compare the between-group differences.
      Results  BFR showed a significant positive correlation with VFA and BMI (R=0.784 and R=0.731, respectively; P<0.05) and a significant negative correlation with VFD (R=−0.814; P<0.05). The area under the curve (AUC) values of BFR, VFA, BMI, and VFD for diagnosing postoperative complications were all >0.7, and the optimal cut-off value for BFR was 28.95. The BFR-Low group had fewer postoperative complications, lower intraoperative indicators, a shorter hospitalization time, and lower costs than the BFR-High group (P<0.05). Through validation using multiple models, it has been found that BFR holds significant diagnostic value in predicting complications. The BFR-High group showed better survival outcomes (P<0.05).
      Conclusions  There was a close association between BFR and BMI, VFA, and VFD. Reasonable control of BFR or moderate increases may contribute to preventing and managing postoperative complications in patients with gastric cancer, thereby improving long-term survival.

     

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