细胞自噬调控在肿瘤中作用的研究进展

李淑敏; 王之枫; 刘宗绪; 赵慧兰; 王振; 李兰青; 杨飞; 柯坤彬; 李艳平; 石西南

doi:10.12354/j.issn.1000-8179.2023.20230826

细胞自噬调控在肿瘤中作用的研究进展

doi: 10.12354/j.issn.1000-8179.2023.20230826

李淑敏^1,,
王之枫²,
刘宗绪¹,
赵慧兰¹,
王振³,
李兰青³,
杨飞³,
柯坤彬⁴,
李艳平¹,
石西南^{5, 6, 7, ,}

1.
云南中医药大学中药学院（昆明市650500）
2.
云南中医药大学第一临床医学院
3.
云南中医药大学第三附属医学院
4.
昆明医科大学第一附属医院泌尿外科
5.
云南中医药大学基础医学院
6.
植物化学与西部植物资源持续利用国家重点实验室
7.
云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室

基金项目: 本文课题受国家自然科学基金地区基金项目（编号：82060862）、云南省科技厅-云南中医药大学联合项目（编号：202101AZ070001-003）、云南省科技厅应用基础面上项目（编号：202301AT070098）、植物化学与西部植物资源持续利用国家重点实验室开放课题项目（编号：P2022-KF04）和云南省南药可持续利用研究重点实验室开放课题项目（编号：202105AG070012XS23056）资助

详细信息

作者简介:
李淑敏：专业方向为肿瘤药理学研究

通讯作者:
石西南　xilancixiang@ynutcm.edu.cn

计量
- 文章访问数: 53
- HTML全文浏览量: 10
- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2023-08-24
- 录用日期: 2023-10-23
- 修回日期: 2023-10-20

Research progress on autophagy regulation in tumors

1.
School of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
2.
The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China
3.
The Third Affiliated College of Yunnan University of Chinese Medicine, Kunming 650500, China
4.
Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming 650500, China
5.
School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
6.
State Key Laboratory of Phytochemistry and Sustainable Utilization of Plant Resources in Western China, Kunming 650500, China
7.
Key Laboratory of Sustainable Utilization of Southern Chinese Medicine in Yunnan Province, School of Traditional Chinese Medicine, Yunnan University of Chinese Medience, Kunming 650500, China

Funds: This work was supported by the National Natural Science Foundation of China (No. 82060862), Joint Project of Yunnan Provincial Department of Science and Technology and Yunnan University of Traditional Chinese Medicine (No. 202101AZ070001-003), Applied Basic Research Project of Yunnan Provincial Science and Technology Department (No. 202301AT070098), Open Project of State Key Laboratory of Phytochemistry and Sustainable Utilization of Plant Resources in Western China (No. P2022-KF04) and Open Research Project of Key Laboratory for Sustainable Utilization of Southern Chinese Medicine in Yunnan Province (No. 202105AG070012XS23056)

More Information

Corresponding author: Xinan Shi; E-mail: xilancixiang@ynutcm.edu.cn

摘要

摘要: 自噬是溶酶体介导的细胞自行消化，其构成了一个被损坏的细胞器和长寿命蛋白质的循环动态途径，在机体内环境稳态和肿瘤发生机制中发挥着重大作用，以保证细胞在营养不足、肿瘤微环境等应激条件下可获得持续利用的能量，并以此来维持体内平衡及生存能力。自噬不仅依赖于肿瘤中的环境、细胞种类和阶段，而且还受肿瘤细胞与微环境之间相互串扰的调节。自噬在肿瘤的早期阶段能抑制肿瘤发生，然而肿瘤晚期阶段自噬促进肿瘤发生，并增加肿瘤细胞生长和转移。本文将就自噬机制及其在肿瘤细胞增殖发展中的作用进行综述，深入研究自噬在癌症生物学中作用，有助于针对自噬相关靶点抗肿瘤的新药设计和临床转化研究。
- 自噬 /
- 自噬缺陷 /
- 肿瘤微环境
Abstract: Autophagy is a lysosome-mediated cellular self-digestion process that participates in the dynamic recycling of damaged organelles and long-lived proteins. Within the body, it plays a significant role in maintaining homeostasis and in tumorigenic processes. Autophagy ensures that cells can obtain sustained energy under stress conditions, such as nutrient deficiency and the tumor microenvironment, thereby maintaining their internal balance and survivability. Autophagy is not only dependent on the environment, cell type, and tumor stage, but is also regulated by the interaction between tumor cells and their microenvironment. Autophagy can inhibit tumorigenesis in the early stage of cancer; however, it promotes tumorigenesis and increases tumor cell growth and metastasis in the later stage. This article reviews the mechanism of autophagy and its role in the proliferation and development of tumor cells. In-depth understanding of the role of autophagy in cancer biology will facilitate the design of new drugs and clinical translational studies targeting autophagy-related molecules for anti-tumor therapy.
- autophagy /
- autophagy defect /
- tumor microenvironment

HTML全文

图 1 自噬过程的分子信号转导^[6]

下载: 全尺寸图片幻灯片

图 2 自噬缺陷促肿瘤细胞增生的分子信号通路^[7]

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图 3 自噬促进肿瘤细胞增生的分子信号通路^[6]

下载: 全尺寸图片幻灯片

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