细胞自噬调控在肿瘤中作用的研究进展

李淑敏 王之枫 刘宗绪 赵慧兰 王振 李兰青 杨飞 柯坤彬 李艳平 石西南

李淑敏, 王之枫, 刘宗绪, 赵慧兰, 王振, 李兰青, 杨飞, 柯坤彬, 李艳平, 石西南. 细胞自噬调控在肿瘤中作用的研究进展[J]. 中国肿瘤临床, 2023, 50(19): 1006-1010. doi: 10.12354/j.issn.1000-8179.2023.20230826
引用本文: 李淑敏, 王之枫, 刘宗绪, 赵慧兰, 王振, 李兰青, 杨飞, 柯坤彬, 李艳平, 石西南. 细胞自噬调控在肿瘤中作用的研究进展[J]. 中国肿瘤临床, 2023, 50(19): 1006-1010. doi: 10.12354/j.issn.1000-8179.2023.20230826
Shumin Li, Zhifeng Wang, Zongxu Liu, Huilan Zhao, Zhen Wang, Lanqing Li, Fei Yang, Kunbin Ke, Yanping Li, Xinan Shi. Research progress on autophagy regulation in tumors[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(19): 1006-1010. doi: 10.12354/j.issn.1000-8179.2023.20230826
Citation: Shumin Li, Zhifeng Wang, Zongxu Liu, Huilan Zhao, Zhen Wang, Lanqing Li, Fei Yang, Kunbin Ke, Yanping Li, Xinan Shi. Research progress on autophagy regulation in tumors[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(19): 1006-1010. doi: 10.12354/j.issn.1000-8179.2023.20230826

细胞自噬调控在肿瘤中作用的研究进展

doi: 10.12354/j.issn.1000-8179.2023.20230826
基金项目: 本文课题受国家自然科学基金地区基金项目(编号:82060862)、云南省科技厅-云南中医药大学联合项目(编号:202101AZ070001-003)、云南省科技厅应用基础面上项目(编号:202301AT070098)、植物化学与西部植物资源持续利用国家重点实验室开放课题项目(编号:P2022-KF04)和云南省南药可持续利用研究重点实验室开放课题项目(编号:202105AG070012XS23056)资助
详细信息
    作者简介:

    李淑敏:专业方向为肿瘤药理学研究

    通讯作者:

    石西南 xilancixiang@ynutcm.edu.cn

Research progress on autophagy regulation in tumors

Funds: This work was supported by the National Natural Science Foundation of China (No. 82060862), Joint Project of Yunnan Provincial Department of Science and Technology and Yunnan University of Traditional Chinese Medicine (No. 202101AZ070001-003), Applied Basic Research Project of Yunnan Provincial Science and Technology Department (No. 202301AT070098), Open Project of State Key Laboratory of Phytochemistry and Sustainable Utilization of Plant Resources in Western China (No. P2022-KF04) and Open Research Project of Key Laboratory for Sustainable Utilization of Southern Chinese Medicine in Yunnan Province (No. 202105AG070012XS23056)
More Information
  • 摘要: 自噬是溶酶体介导的细胞自行消化,其构成了一个被损坏的细胞器和长寿命蛋白质的循环动态途径,在机体内环境稳态和肿瘤发生机制中发挥着重大作用,以保证细胞在营养不足、肿瘤微环境等应激条件下可获得持续利用的能量,并以此来维持体内平衡及生存能力。自噬不仅依赖于肿瘤中的环境、细胞种类和阶段,而且还受肿瘤细胞与微环境之间相互串扰的调节。自噬在肿瘤的早期阶段能抑制肿瘤发生,然而肿瘤晚期阶段自噬促进肿瘤发生,并增加肿瘤细胞生长和转移。本文将就自噬机制及其在肿瘤细胞增殖发展中的作用进行综述,深入研究自噬在癌症生物学中作用,有助于针对自噬相关靶点抗肿瘤的新药设计和临床转化研究。

     

  • 图  1  自噬过程的分子信号转导[6]

    图  2  自噬缺陷促肿瘤细胞增生的分子信号通路[7]

    图  3  自噬促进肿瘤细胞增生的分子信号通路[6]

  • [1] de Duve C, Wattiaux R. Functions of lysosomes[J]. Annu Rev Physiol, 1966, 28:435-492.
    [2] Li XH, He SK, Ma BY. Autophagy and autophagy-related proteins in cancer[J]. Mol Cancer, 2020, 19(1):12.
    [3] Zhang SY, Song XY, Li Y, et al. Tumor-associated macrophages: a promising target for a cancer immunotherapeutic strategy[J]. Pharmacol Res, 2020, 161:105111.
    [4] Debnath J, Gammoh N, Ryan KM. Autophagy and autophagy-related pathways in cancer[J]. Nat Rev Mol Cell Biol, 2023, 24(8):560-575.
    [5] Liu SZ, Yao SJ, Yang H, et al. Autophagy: regulator of cell death[J]. Cell Death Dis, 2023, 14(10):648.
    [6] Camuzard O, Santucci-Darmanin S, Carle GF, et al. Autophagy in the crosstalk between tumor and microenvironment[J]. Cancer Lett, 2020, 490:143-153.
    [7] White E, Karp C, Strohecker AM, et al. Role of autophagy in suppression of inflammation and cancer[J]. Curr Opin Cell Biol, 2010, 22(2):212-217.
    [8] Ren YQ, Wang RZ, Weng SY, et al. Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis[J]. Mol Cancer, 2023, 22(1):130.
    [9] Chung C, Seo W, Silwal P, et al. Crosstalks between inflammasome and autophagy in cancer[J]. J Hematol Oncol, 2020, 13(1):100.
    [10] Lv Q, Wang W, Xue JF, et al. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer[J]. Cancer Res, 2012, 72(13):3238-3250.
    [11] Mathew R, Kongara S, Beaudoin B, et al. Autophagy suppresses tumor progression by limiting chromosomal instability[J]. Genes Dev, 2007, 21(11):1367-1381.
    [12] Huang JF, Duran A, Reina-Campos M, et al. Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor[J]. Cancer Cell, 2018, 33(4):770-784.
    [13] Wang XR, Jiang ZB, Xu C, et al. Andrographolide suppresses non-small-cell lung cancer progression through induction of autophagy and antitumor immune response[J]. Pharmacol Res, 2022, 179:106198.
    [14] Fu LL, Cheng Y, Liu B. Beclin-1: autophagic regulator and therapeutic target in cancer[J]. Int J Biochem Cell Biol, 2013, 45(5):921-924.
    [15] Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1[J]. Nature, 1999, 402(6762):672-676. doi: 10.1038/45257
    [16] White E. The role for autophagy in cancer[J]. J Clin Invest, 2015, 125(1):42-46.
    [17] Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis[J]. Cancer Cell, 2006, 10(1):51-64.
    [18] Giuliani C. The flavonoid quercetin induces AP-1 activation in FRTL-5 thyroid cells[J]. Antioxidants, 2019, 8(5):112.
    [19] Ahn CH, Jeong EG, Lee JW, et al. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers[J]. APMIS, 2007, 115(12):1344-1349.
    [20] Hashemi M, Nadafzadeh N, Imani MH, et al. Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches[J]. Cell Commun Signal, 2023, 21(1):32.
    [21] Yan RL, Chen RH. Autophagy and cancer metabolism-the two-way interplay[J]. IUBMB Life, 2022, 74(4):281-295.
    [22] Wen ZF, Liu HX, Gao R, et al. Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1[J]. J Immunother Cancer, 2018, 6(1):151.
    [23] Xia HJ, Li SS, Li X, et al. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis[J]. JCI Insight, 2020, 5(18):e141115
    [24] Yamamoto K, Venida A, Yano J, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I[J]. Nature, 2020, 581(7806):100-105. doi: 10.1038/s41586-020-2229-5
    [25] Tittarelli A, Janji B, van Moer K, et al. The selective degradation of synaptic connexin 43 protein by hypoxia-induced autophagy impairs natural killer cell-mediated tumor cell killing[J]. J Biol Chem, 2015, 290(39):23670-23679.
    [26] Baginska J, Viry E, Berchem G, et al. Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia[J]. Proc Natl Acad Sci U S A, 2013, 110(43):17450-17455.
    [27] Thongchot S, Jamjuntra P, Therasakvichya S, et al. Interleukin-8 released by cancer-associated fibroblasts attenuates the autophagy and promotes the migration of ovarian cancer cells[J]. Int J Oncol, 2021, 58(5):14. doi: 10.3892/ijo.2021.5194
    [28] Sousa CM, Biancur DE, Wang XX, et al. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion[J]. Nature, 2016, 540(7631):150.
    [29] Divé I, Klann K, Michaelis JB, et al. Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner[J]. Cell Death Discov, 2022, 8(1):409.
    [30] Yang SH, Wang XX, Contino G, et al. Pancreatic cancers require autophagy for tumor growth[J]. Genes Dev, 2011, 25(7):717-729.
    [31] Guo JY, Chen HY, Mathew R, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis[J]. Genes Dev, 2011, 25(5):460-470.
    [32] Yim WWY, Mizushima N. Lysosomebiology in autophagy[J]. Cell Discov, 2020, 6:6.
    [33] Low V, Li ZC, Blenis J. Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment[J]. Sci Signal, 2022, 15(759):eabj4220.
    [34] Zamame Ramirez JA, Romagnoli GG, Kaneno R. Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy[J]. Life Sci, 2021, 265:118745.
    [35] Sang J, Gan L, Zou MF, et al. Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy[J]. Cancer Lett, 2022, 526:352-362.
  • 加载中
图(3)
计量
  • 文章访问数:  53
  • HTML全文浏览量:  10
  • PDF下载量:  21
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-08-24
  • 录用日期:  2023-10-23
  • 修回日期:  2023-10-20

目录

    /

    返回文章
    返回