Abstract: Objective:To analyze the therapeutic effect of repeated hepatectomy on recurrent hepatocellu -lar carcinoma and prognostic factors. Methods:We retrospectively analyzed the clinicopathologic data of 48 patients who underwent repeated hepatectomy for recurrent hepatocellular carcinoma between July 1995and July 2003. Overall survival rate and disease-free survival (DFS) rate were calculated by Kaplan-Meier meth-od. Prognostic factors were analyzed by univariate and multivariate analysis. Results: The median survival of 48patients was 36.4 months. The overall 1-, 3-, and 5-year survival rates were 81.3%,45.8%, and27.1%, re-spectively. The disease-free 1-, 3-, and 5-year survival rates were 70.8% ,25.0% , and16.7% , respectively. Univariate analysis showed that TNM stage of primary tumor , TNM stage of the recurrent tumor, vascular in-vasion, recurrent tumor size (> 5cm) and recurrence-free interval were prognostic risk factors for overall surviv-al. While TNM stage of primary tumor, recurrent tumor size (>5cm), TNM stage of recurrent tumor, vascular invasion, pathological grading of recurrent tumor, preoperative AFP and recurrence-free interval were prognos -tic risk factors for DFS. Multivariate analysis showed that recurrence-free interval and TNM stage of recurrent tumor were independent prognostic risk factors for overall survival. While recurrence-free interval and recur -rent tumor size (> 5cm) were independent prognostic risk factors for DFS. Conclusion:Short recurrence-free in-terval (≤24months), recurrent tumor size (>5cm) and TNM stage of recurrent tumor indicate poor prognosis of patients who received repeated hepatectomy for recurrent hepatocellular carcinoma.