Abstract: Objective:To investigate the effect of preoperative pirarubicin intervention chemotherapy on local advanced breast cancer. Methods:During May2001and April 2006, a total of 68patients with local advanced breast cancer were col -lected and randomly divided into 2 groups: 36patients in the preoperative intervention chemotherapy group (Group A) and 32patients in the preoperative venous chemotherapy (Group B). For patients in Group A, Seldinger technique (through ar-teria femoralis and arteria ulnaris) was used, a catheter was placed on the proximal side of the junction of subclavicular ar -tery and the top of interathoracic artery via corlicaus and chemotherapeutic drugs were instilled (Pirarubicin 60-80mg, 5-Flu -orouracil 750 mg, Cytoxan 800 mg). The 32patients in Group B received preoperative chemotherapy intravenously (Pirarubi-cin 60-80mg, iv, d 1, 5-Fluorouracil 750 mg, iv, d 1, Cytoxan 800 mg, iv, d 1). Results: The complete response rate and partial response rate were 13.9% and 75.0% in Group A, and were3.1% and 56.3% in Group B, with significant diference be-tween the two groups (P<0.05, χ2=7.87). Conclusion:The arterial infusion chemotherapy through the arteria ulnaris has bet -ter effect on local advanced breast cancer.