赵成茂, 张宝亮, 赵成鹏, 马建萍, 马贞秀. 放射治疗对乳腺导管原位癌保乳术后复发率的影响一项基于随机对照试验的Meta分析[J]. 中国肿瘤临床, 2012, 39(11): 772-776. DOI: 10.3969/j.issn.1000-8179.2012.11.005
引用本文: 赵成茂, 张宝亮, 赵成鹏, 马建萍, 马贞秀. 放射治疗对乳腺导管原位癌保乳术后复发率的影响一项基于随机对照试验的Meta分析[J]. 中国肿瘤临床, 2012, 39(11): 772-776. DOI: 10.3969/j.issn.1000-8179.2012.11.005
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Chengmao ZHAO, Baoliang ZHANG, Chengpeng ZHAO, Jianping MA, Zhenxiu MA. Effect of Adjuvant Radiation after Breast Conserving Surgery on the Risk of Recurrence for Patients with Ductal Carcinoma In Situ of the Breast: A Meta Analysis Based on Randomized Controlled Trials[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(11): 772-776. DOI: 10.3969/j.issn.1000-8179.2012.11.005
Citation: Chengmao ZHAO, Baoliang ZHANG, Chengpeng ZHAO, Jianping MA, Zhenxiu MA. Effect of Adjuvant Radiation after Breast Conserving Surgery on the Risk of Recurrence for Patients with Ductal Carcinoma In Situ of the Breast: A Meta Analysis Based on Randomized Controlled Trials[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(11): 772-776. DOI: 10.3969/j.issn.1000-8179.2012.11.005
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放射治疗对乳腺导管原位癌保乳术后复发率的影响一项基于随机对照试验的Meta分析

Effect of Adjuvant Radiation after Breast Conserving Surgery on the Risk of Recurrence for Patients with Ductal Carcinoma In Situ of the Breast: A Meta Analysis Based on Randomized Controlled Trials

    摘要
  • 摘要:
      目的  用Meta分析方法评价放射治疗能否降低乳腺导管原位癌(DCIS)保乳术后的复发率。
      方法  计算机检索PubMed、EMBASE、CochraneLibrarlv、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库、万方数据库, 手工检索搜集有关放疗辅助治疗DCIS的随机对照试验, 用RevMan5.0软件进行统计分析。
      结果  纳入4篇随机对照试验共计2701例乳腺癌患者, Meta分析结果显示, 保乳术后联合放射治疗与单纯手术比较, 乳腺导管原位癌复发率较低, 两者相比差异有统计学意义(RR=0.45, 95%CI: 037~0.55)亚组分析均提示辅助放疗可以降低其复发率。
      结论  DCIS患者保乳术后放射治疗可以降低其复发率, 高危患者可能受益更多。

     

    Abstract:
      Objective  This study aims to determine whether adjuvant radiotherapy could reduce the recurrence of ductal carcinoma in situ(DCIS).
      Methods  PubMed, Embase, Cochrane Library, Chinese biomedical literature database, Chinese Scientific Journal full-text database, Chinese Journal full-text database, WANGFANG, and the bibliographies of retrieved articles for randomized controlled trials were searched to compare the risk of recurrence in patients treated with and without radiotherapy.The data were analyzed using Review Manager 5.0.
      Results  Four randomized controlled trials in 2, 701 participants were included in this study.The results of the meta analysis showed that radiotherapy following breast conserving surgery significantly affected the risk of recurrence in DCIS treatment compared with surgery alone.All the analyzed subgroups benefited from the application of radiotherapy.
      Conclusion  Adjuvant radiotherapy can reduce the risk of recurrence in DCIS treatment, from which participants with high risk may benefit more than those with low risk.

     

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