Abstract: Neurofibroma is a benign tumor derived from the peripheral nerve and could occur in any part of the body.Neurofibroma with multiple calcifications is uncommon and is easily misdiagnosed.Accurate preoperative diagnosis for neurofibroma is difficult because of lack of clinical symptoms and imaging characteristics.This study aims to retrospectively analyze the clinical features and imaging performance of one neurofibroma case confirmed via surgery and pathology in the Department of Bone and Soft Tissue Tumor of our hospital. Related studies were reviewed to explore the clinical features, imaging findings, and differential diagnosis of neurofibroma with multiple calcifications and to improve the understanding of this disease.