Abstract:
Objective The study aims to investigate the expression of L1 cell adhesion molecules(L1-CAM) in invasion micropapillary carcinoma(IMPC) and to analyze its clinical significance.
Methods L1-CAM expression was analyzed in 97 IMPC cases and 95 invasive ductal carcinoma–not otherwise specified(IDC-NOS) cases via immunohistochemistry. The correlation of L1-CAM expression with clinicopathologic characteristics, which include the prognosis IMPC patients, was determined.
Results The rate of L1-CAM expression in IMPC(50.5%) is significantly higher than that of IDC-NOS(18.9%). L1-CAM expression is also associated with histological grade, vessel invasion, lymph node metastasis, L1-CAM vessels, and protein p53 expression(P < 0.05), whereas it is negatively associated with ER and PR(P < 0.05). L1-CAM was predominantly expressed in the cell-cell interface of the cell clusters of IMPC and in the stroma vascular endothelial cells. Univariate analysis results indicate that expression of L1 is a risk factor that can predict the survival of IMPC patients(P < 0.05). Multivariate analyses results from a Cox's proportional hazards model show that a high expression of L1-CAM is an independent risk factor for the death of IMPC patients.
Conclusion This study suggests that L1-CAM expression may have an important function in collective cell growth and is significantly associated with tumor invasion and metastasis. L1-CAM can be considered as biomarkers of prognosis and as a new target for IMPC therapy.
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