胃癌组织中SNCG和CXCR4 mRNA的表达及临床意义

郑淑芳; 时丽芳; 于健

doi:10.3969/j.issn.1000-8179.20140242

胃癌组织中SNCG和CXCR4 mRNA的表达及临床意义

Expression of SNCG and CXCR4 mRNAs in gastric adenocarcinoma and its clinical significance

摘要

摘要:
目的研究SNCG和CXCR4在胃癌和正常胃黏膜组织中的表达，探讨其在胃癌发生、发展、浸润转移中的作用。
方法应用RT-PCR法检测不同组织中SNCG和CXCR4 mRNA的表达情况。
结果 SNCG和CXCR4 mRNA在胃癌组织中的表达量明显高于正常胃黏膜组织（P < 0.01）；胃癌组织中SNCG mRNA的表达量与癌组织的浸润深度和淋巴结转移有关（P < 0.05，P < 0.01），CXCR4mRNA的表达量与淋巴结转移有关（P < 0.01）；胃癌组织中SNCG mRNA与CXCR4 mRNA的表达量呈正相关（r=0.346，P < 0.05）。
结论 SNCG和CXCR4在胃癌组织中高表达，可能与胃癌的发生、发展、浸润、转移密切相关。

Abstract:
Objective To detect expression of SNCG and CXCR4 mRNA in gastric adenocarcinoma and evaluate its function in carcinogenesis, progression, infiltration, and metastasis, as well as the correlation of these proteins.
Methods The expression of SNCG and CXCR4 mRNAs was detected using reverse transcription-polymerase chain reaction in gastric adenocarcinoma and normal gastric mucosa.
Results The expression of SNCG and CXCR4 mRNAs was obviously higher in gastric adenocarcinoma than in normal gastric mucosa (P < 0.01). The expression of SNCG mRNA was closely correlated with tumor infiltration depth (P < 0.05) and lymph node metastasis (P < 0.01). The expression of CXCR4 mRNA closely correlated with lymph node metastasis (P < 0.01). The expression of SNCG and CXCR4 mRNAs positively correlated in 29 cases of gastric adenocarcinoma (r=0.346, P < 0.05).
Conclusion SNCG and CXCR4 may be overexpressed in tumor tissue and may have important functions in tumorigenesis, progression, infiltration, and metastasis of gastric adenocarcinoma.

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