葛瑞祥①, 盛莉莉②, 徐善水①, 刘银华③, 徐国祥③, 陈三送①, 毛捷①. 12-LOX在神经胶质瘤中的表达及临床意义*[J]. 中国肿瘤临床, 2015, 42(19): 953-956. DOI: 10.3969/j.issn.1000-8179.2015.19.799
引用本文: 葛瑞祥①, 盛莉莉②, 徐善水①, 刘银华③, 徐国祥③, 陈三送①, 毛捷①. 12-LOX在神经胶质瘤中的表达及临床意义*[J]. 中国肿瘤临床, 2015, 42(19): 953-956. DOI: 10.3969/j.issn.1000-8179.2015.19.799
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Ruixiang GE, Lili SHENG, Shanshui XU, Yinhua LIU, Guoxiang XU, Sansong CHEN, Jie MAO. Expression and significance of 12-lipoxygenase in human glioma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(19): 953-956. DOI: 10.3969/j.issn.1000-8179.2015.19.799
Citation: Ruixiang GE, Lili SHENG, Shanshui XU, Yinhua LIU, Guoxiang XU, Sansong CHEN, Jie MAO. Expression and significance of 12-lipoxygenase in human glioma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(19): 953-956. DOI: 10.3969/j.issn.1000-8179.2015.19.799
shu

12-LOX在神经胶质瘤中的表达及临床意义*

Expression and significance of 12-lipoxygenase in human glioma

    摘要
  • 摘要: 目的：研究12- 脂氧合酶（12-lipoxygenase ，12-LOX）在神经胶质瘤中的表达及其临床意义。方法：免疫组织化学法检测40例神经胶质瘤组织和10例正常脑组织中12-LOX 表达，结合临床随访资料探讨其表达与预后的相关性。结果：正常脑组织中12-LOX 呈弱阳性表达，神经胶质瘤组织中强阳性表达率为72.5% ，差异有统计学意义（P < 0.05）。 12-LOX 强阳性表达与神经胶质瘤病理级别相关，差异有统计学意义（P = 0.012），与患者性别、年龄、肿瘤大小、KPS 评分无关。12-LOX 强阳性表达患者中位无瘤生存期明显低于与弱阳性表达患者（P < 0.05）。 结论：12-LOX 在神经胶质瘤中异常表达，其表达差异与神经胶质瘤的病理级别相关，与预后密切相关。

     

    Abstract: Objective:To investigate the expression and clinical significance of 12-lipoxygenase (12-LOX) in glioma. Methods: 12-LOX expression in40glioma cases and 10normal human-brain tissues was assayed by immunohistochemistry. Clinicopathological data were analyzed to reveal the association between12-LOX expression and prognosis of glioma patients. Results:12-LOX was weak -ly expressed in the normal human brain tissues, whereas 12- LOX was strongly expressed (72.5% ) in glioma tissues (P<0.05). The strong 12-LOX expression was correlated with the histopathological grading of glioma ( P=0.012), whereas 12-LOX expression was not correlated with factors such as patient gender and age, tumor size, and Karnofsky Performance Score. Median survival time was longer in the group with low 12-LOX expression ( 25.6 months) than in the group with high 12-LOX expression ( 13.2 months) ( P<0.05). Con -clusion: Abnormal12-LOX expression is implicated in glioma.12-LOX expression was correlated with the histopathological grading of glioma and was closely associated with patient prognosis.

     

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