Abstract: With advances in medical technology and tumor research, the cure and survival rates in cancer patients are increasing. Quality of life (QOL) for cancer patients has become a focus of attention. Cancer-related fatigue (CRF) is one of the most common symptoms in cancer patients, and is related to the tumor itself or tumor treatment. CRF develops quickly and the effect is prolonged, severely impairing QOL in cancer patients. Screening, evaluation, and effective intervention for CRF are very important. This article summerizes the progress of research on CRF and interprets the 2018 update of the National Comprehensive Cancer Network guidelines on CRF.