贾宏琴, 李帅, 韩芸蔚, 刘芳芳, 李伟东, 付丽. 染色体8q24区域异常在乳腺癌中的研究进展[J]. 中国肿瘤临床, 2019, 46(3): 150-153. DOI: 10.3969/j.issn.1000-8179.2019.03.157
引用本文: 贾宏琴, 李帅, 韩芸蔚, 刘芳芳, 李伟东, 付丽. 染色体8q24区域异常在乳腺癌中的研究进展[J]. 中国肿瘤临床, 2019, 46(3): 150-153. DOI: 10.3969/j.issn.1000-8179.2019.03.157
shu
Jia Hongqin, Li Shuai, Han Yunwei, Liu Fangfang, Li Weidong, Fu Li. Research advances of chromosomal 8q24 aberrance in breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(3): 150-153. DOI: 10.3969/j.issn.1000-8179.2019.03.157
Citation: Jia Hongqin, Li Shuai, Han Yunwei, Liu Fangfang, Li Weidong, Fu Li. Research advances of chromosomal 8q24 aberrance in breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 46(3): 150-153. DOI: 10.3969/j.issn.1000-8179.2019.03.157
shu

染色体8q24区域异常在乳腺癌中的研究进展

Research advances of chromosomal 8q24 aberrance in breast cancer

    摘要
  • 摘要: 近年来基因芯片、高通量测序技术，大规模发现基因组拷贝数变异和单核苷酸多态性等异常改变，其中8号染色体长臂2区4带（8q24）的高频变异在乳腺癌发生发展中的意义日益受到关注。8q24区域包含MYC、PSCA等癌基因和乳腺癌相关风险位点，在乳腺癌中该区域高频扩增与乳腺癌的发生发展及预后密切相关。本文将对乳腺癌中8q24区域的扩增及相关风险位点的特征及乳腺癌相关基因的作用进行综述。

     

    Abstract: With the development and application of microarray and high-throughput sequencing technology, it is possible to genomically scan breast cancer associated CNV and SNPs. Multiple researches showed that the frequent aberrance of 8q24 was associated with breast cancer. Oncogenes such as MYC, PSCA and breast cancer associated loci are located in 8q24, and frequent amplification of 8q24 was proposed to be related with breast cancer development and prognosis. This review summarizes the association of the 8q24 amplification and SNPs with breast cancer by correlated genes on this locus.

     

    • HTML全文
    • 参考文献(30)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回