肿瘤异质性-精准临床诊治的挑战

白日兰 崔久嵬

白日兰, 崔久嵬. 肿瘤异质性-精准临床诊治的挑战[J]. 中国肿瘤临床, 2020, 47(21): 1081-1087. doi: 10.3969/j.issn.1000-8179.2020.21.341
引用本文: 白日兰, 崔久嵬. 肿瘤异质性-精准临床诊治的挑战[J]. 中国肿瘤临床, 2020, 47(21): 1081-1087. doi: 10.3969/j.issn.1000-8179.2020.21.341
BAI Rilan, Cui Jiuwei. Tumor heterogeneity: the great challenge in precision clinical diagnosis and treatment[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 47(21): 1081-1087. doi: 10.3969/j.issn.1000-8179.2020.21.341
Citation: BAI Rilan, Cui Jiuwei. Tumor heterogeneity: the great challenge in precision clinical diagnosis and treatment[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 47(21): 1081-1087. doi: 10.3969/j.issn.1000-8179.2020.21.341

肿瘤异质性-精准临床诊治的挑战

doi: 10.3969/j.issn.1000-8179.2020.21.341
基金项目: 

本文课题受国家重点研发项目 2016YFC1303804

吉林省科技厅科技发展计划项目 20190303146SF

详细信息
    作者简介:

    白日兰, 专业方向为肿瘤综合诊治及基础研究。E-mail:bairilan@foxmail.com

    崔久嵬 教授,博士生导师,现任吉林大学第一医院肿瘤中心副主任,肿瘤科主任,吉林省生物治疗重点实验室负责人。兼任中国抗癌协会青年理事会副理事长、中国研究型医院生物治疗委员会副主任委员、中国研究型医院分子诊断委员会副主任委员、中国医药质量管理协会细胞治疗质量控制与研究专业委员会常委、中华医学生物免疫学会常务委员、中国抗癌协会营养与支持委员会肿瘤免疫营养学组组长、中国抗癌协会肿瘤营养专业委员会常委、中国抗癌协会肿瘤科普防治专业委员会常委、中国临床肿瘤学会理事、国家抗肿瘤药物临床应用监测专家委员会委员、中华医学会肿瘤学分会第十一届肺癌专家委员会委员等。主要研究方向为肿瘤发病机制及免疫治疗研究。负责及参与32项国家、省部级课题。曾获2020年吉林省自然科学奖一等奖,2018年吉林省青年科技奖特别奖 1项,中国分析测试协会科学技术奖二等奖 1项,吉林省科学技术成果一等奖1项,二等奖3项;获吉林省突出贡献中青年专业技术人才、吉林省卫生系统第二次拔尖创新人才、白求恩名师、吉林省高校双百人才和长春市百名优秀科技工作者称号

    通讯作者:

    崔久嵬, E-mail:cuijw@jlu.edu.cn

Tumor heterogeneity: the great challenge in precision clinical diagnosis and treatment

Funds: 

the National Key Research and Development Program of China 2016YFC1303804

the Science and Technology Development Project of Science and Technology of Jilin Province 20190303146SF

More Information
  • 摘要: 肿瘤异质性是肿瘤演化过程中出现的一个普遍而又至关重要的表现特征,是肿瘤形成及进一步演进的重要支撑点。尽管近几年,肿瘤异质性内在规律和形成机制等方面的研究有诸多新进展,但肿瘤异质性仍是实现临床精准诊治、克服耐药问题的重大挑战。近几年,随着高通量测序和单细胞测序技术的发展和不断完善,对肿瘤单个细胞或全基因组测序已逐步揭示肿瘤异质性的时空变异和分子机制。本篇文章对肿瘤异质性的复杂性、形成机制和对肿瘤演进的影响以及对临床诊治带来的挑战的最新研究进展进行综述。

     

  • 图  1  肿瘤异质性的组成及影响

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  • 收稿日期:  2020-04-03
  • 刊出日期:  2020-12-26

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