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摘要: 近20年来,多发性骨髓瘤(multiple myeloma,MM)治疗领域出现了划时代的进步。随着免疫调节剂(immunomodulatory drugs,IMiDs)、蛋白酶体抑制剂(proteasome inhibitors,PIs)的出现和普及,患者的治疗疗效明显提高,生存期显著延长,上述两类药物以及自体造血干细胞移植(autologous stem cell transplantation,ASCT)已成为MM治疗的基石。同时,新的药物仍在不断涌现。如新一代的IMiDs、PIs,抗体类药物及其衍生药物及小分子靶向性治疗药物,还出现了嵌合抗原受体T细胞免疫治疗(chimeric antigen receptor T-cell immunotherapy,CAR-T)等手段。上述治疗在MM中均显示出良好的前景。本文旨在对MM领域新药的研发和应用进行综述。Abstract: The treatment for patients of multiple myeloma (MM) has significantly improved over the past 20 years. With the introduction of immunomodulatory drugs (IMiDS) and proteasome inhibitors (PIs), the response rate and survival of patients with MM have remarkably increased. Currently, IMiDS, PIs, and autologous stem cell transplantation (ASCT) have become the cornerstone of MM treatment. However, numerous new treatments, such as the next generation of IMiDS and PIs, antibody drugs and their derivatives, smallmolecule-targeted therapy drugs, chimeric antigen receptor T-cell immunotherapy (CAR-T), and other cell therapies, are emerging. These treatments have shown promising prospects in treating MM. In this study, we aim to review the development and application of these highly appealing new drugs and therapies for MM.
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