Abstract: Objective : To investigate the correlation between the expressions of CD44V6、nm23-H 1 products in gastric carcinoma and regional lymph nodes with clinicopathologic features and prognosisof gastric cancer. Methods : The expressions of CD44V6、nm23-H1 in 110 advanced gastric carcinomaand 613 regional lymph node specimens were examined with immunohistochemical S-P technic. Results : The positive rate of CD44V6 was 65.5% and 89.4%, whereas the positive rate of nm23-H1 was39.1% and 16.8% in primary gastric cancer and metastasis lymph nodes respectively. The positive ratesof CD44V6、nm23-H1 were correlated with histological types、depth of invasion and node metastasis ofgastric cancer.patients with CD44V6 positive regional lymph nodes had low 5-year survival rate (P<0.01), whereas patients with nm23-H1 positive regional lymph nodes had high 5-year survival rate (PG0.01). Conclusion : To detect CD44V6、nm23-H1 by immunohistochemistry would be useful in assess-ing tumor progression and lymphatic metastasis and in predicting prognosis of gastric cancer.