Abstract: Objective: To observe the differentiation induction effects of JLC on tumor cells.Methods: In vitro cell culture, MTT titration, NBT reduction and phagocytosis determination were e m ployed to study the effects of JLC on HL-60 cells. Results: After 3 or 5 days' culture with JLC at lx10^-6 and 10^-9mg/ml the proportion of early myeloblast decreased, while the proportion of mid- and late myeloblast increased significantly. The NBT reduction ability and the phagocytosis of horse radish peroxidase of the cells increased significantly too. The effects are parallel to that of retinoic acid. JLC promoted luciffer yellow transfer between tumor cells. Conclusion: JLC could obviously promote the morphological and functional differentiation and maturation. That showed the differentiation induction effects of JLC on tumor cells.