Abstract: Objective: To evaluate therapeutic effect of Aiben (Ibandronate) combined with local radiotherapy in cancer patients with limited bone metastases. Methods: 80 cancer patients with limited bone metastases were divided randomly into two groups, the treated group (40 cases) received intra-venously ibandronate combined with local radiotherapy while the control group (40 cases) received local radiotherapy only. Results: Response rate of bone pain relief was 92.5V in the treated group and 82.5% in the control group. There was no statistical significant difference between two groups (P>0.05).Concerning total recalcification rate, 76.7% and 27.8% respectively in two groups, the therapeutic effect in the treated group was much better than that in the control group (P<0.001). Comparing with control group, the treated group had fewer new bone metastases (P<0.05). And one-year survival rate in treated group was much higher than that in control group. There was no statistical difference in adverse events between the two groups. Conclusion: there were some advantages of a fast and substantial pain relief, a high recalcification rate of lytic lesion, a reduction of new bone metastases and a high survival rate in Aiben treated group.