Abstract: Objective: To analyse the effect of the chemotherapy combined radiaotherapy on in-lermediate and advanced nasopharyngeal carcinoma. Methods: Tirty - three cases of inlermediate ad-vanced cervical cancer were treated with radiotherapy (n=33) and chemotherapy combined radiotherapy (n=51). The tumor mass was measured before and after therapy. The effect of treatments was compared based on the response rates of therapy and survival rates of 5years. Results: The objective response rates completely remissionEpartial remission (CR+PR) in radiotherapy and radiotherapy combined chemotherapy groups were 82.1% and 90.1% (P<0.01), and correspondingly, the survival rates of 5 years in both groups were 42.4% and 66.6% (P< 0.01), respectively. Conclusion: Chemotherapy com-bined radiotherapy might be much more favor of the outcome of intermediate advanced nasopharyngeal carcinoma.