Abstract: Objective: The study investigated the relationship between the standardized uptake value (SUV) and prognosis in patients with non-small cell lung cancer (NSCLC). Methods: 122 patients confirmed NSCLC underwent ¹⁸F-FDG-positron emission tomography (PET) imaging. SUV was calculated in regions of interest(RIO) of pulmonary lesions on PET scans. Results: In the univariate analysis, performance status (P<0.01), stage (P<0.01), Tumor-cell type (P<0.01). SUV greater than 7 (P<0.05), were correlated with bad survival. However, there was no significant difference in gender (P>0.05). Multivariate Cox model analysis indicated that the overall survival was significantly related to performance status (P<0.01), stage(P<0.01), Tumor-cell type(P<0.01) and SUV (P<0.05). Conclusion: The results suggested that the ¹⁸F-FDG uptake in primary NSCLC with PET may play an important prognostic value and could be complementary to other well-identified factors in the decision on adjuvant treatment protocols.