Abstract: Objective: To explore the clinicopathological and immunohistochemical features, differential diagnosis, and prognosis of papillary urothelial neoplasm of lowmalignant potential (PUNLMP), and to reviewthe literature. Methods: Transurethral resection of bladder tumor (TURBT) was performed on all 12 cases of PUNLMP, and pathological sections were made. Microscopic and immunohistochemical evaluations were performed. Results: The average age of the 12 patients was 53.3 years. Hematuria was the chief symptom. The diameters of all lesions were less than 3 cm based on findings with a cystoscope. The features on microscopy were all consistent with the diagnostic criteria of PUNLMP. Follow-ups were obtained for 10 patients, and the durations ranged from 12 to 36 months. No recurrence was found. Conclusion: PUNLMP in the urinary bladder is a distinct type of intermediate tumor with behavior somewhere between benign and malignant tumors that needs a long period of follow-up. Recurrence is rare. Most cases do not progress into carcinoma. PUNLMP should be differentiated from the lowgrade carcinomas as a separate entity.