Abstract: Objective :To compare the effect,toxicity and quality of life(QQL)between Oxaliplatin plus leucovorin and 5-Fluorouracil(L-OHP+CF+5Fu)regimen and Cisplatin plus Leucovorin and 5-Fluorouracil(DDP+CF+5Fu)regimen in primary patients with advanced Gastric Cancer(stage IV). Methods :Group A(34 cases)were treated with L-OHP+CF+5Fu regimen and group B(36 cases)were treated with DDP+CF+5-Fu regimen.Both regimens were repeated every 3 weeks for three cycles.tumor response and cytotoxic reactions were assessed by WHO criteria.QOL was evaluated by clinical benefit response. Results :The response rate(CR+PR)was 52.9% in group A compared to 50.0% in group B(P<0.05).Leukopenia,nausea and vomiting in group B were more serious than those in group A(P<0.01).Peripheral neuritis had higher incidence in group A(P<0.05),but that was slight(within I and II degree).No other serious adverse reactions occurred in either group.Clinial benefit response in group A was higher than that in group B(P<0.05). Conclusion The present study indicated that L-OHP+CF+5-Fu regimen had lower toxicity,longer median survival time and better QOL than DDP+CF+5-Fu regimen for advanced Gastric cancer,however there was no significant statistical difference in the Objective response rate between the two groups.