Abstract: Malignant tumor is one of the main diseases that seriously threaten human health and life. The incidence and mortality have increased year by year. In China, malignant tumors have become the leading cause of death among residents. For a long time, surgery, radiotherapy and chemotherapy have become the three conventional treatment methods of tumor treatment, but many tumors cannot achieve effective treatment. With the changes in the concept of tumor treatment, immunotherapy has become the fourth model of comprehensive tumor treatment and has received increasing attention. On the basis of existing evidence-based medical results, the China Anti-Cancer Association (CACA) combines domestic and foreign guidelines and consensus to formulate a guide for the immunotherapy in malignant tumors, hoping to help physicians engaged in clinical immunotherapy.