Abstract: Both microRNA(miRNA) and epigenetic modifications play crucial roles in tumorigenesis and tumor progression. Scientific findings have revealed that microRNA and epigenetics are intertwined.The mutual interaction between epigenetics and microRNA is carried out mainly through DNA methylation and histone modification, which provides a new orientation for studies on the pathogenesis of tumors.Tumors could be inhibited through the reversible nature of epigenetics to regulate the expression of tumor-related microRNA.These results show great potential in tumor therapy.The present review provides a comprehensive overview of the current literature on microRNA related to tumorous epigenetic modifications.