Abstract: The incidence and mortality rates of gastric cancer in China remain high, highlighting the urgency to explore and optimize an integrated management strategy with Chinese characteristics that covers prevention, screening, diagnosis, treatment, and recovery. The integrative guidelines for gastric cancer were established by the Committee of Gastric Cancer under the guidance of the China Anti-Cancer Association (CACA), building on the previous edition. These guidelines enhance the core concepts of “whole person, whole body, whole journey, and whole information” and further integrate advanced diagnostic and treatment philosophies of multidisciplinary teams into holistic integrative medicine (MDT to HIM). They closely align with the epidemiological characteristics, genetic predispositions, original scientific research achievements, and unique prevention and control practices of the Chinese population. This revision places special emphasis on incorporating the latest domestic research findings while ensuring widespread accessibility to medical services. It show cases the unique advantages of traditional Chinese medicine while incorporating China’s extensive experience in cancer prevention and control, achieving a balanced integration of research evidence, physician experience, and patient needs. The release of these scientific, standardized, and highly practical diagnostic and treatment guidelines are anticipated to provide valuable guidance for medical professionals nationwide, contributing to more precise and efficient gastric cancer prevention and treatment efforts in China, significantly improving patient outcomes, and advancing the implementation of the Healthy China Initiative.