Abstract: Objective:To discuss the influence of combination of64multi-slice spiral computer tomography (MSCT) and C-reac-tive protein ( CRP ) for the preoperative assessment of colon cancers. Methods:Data from130 patients with definitive diagnoses of co -lon cancer in the West China Hospital of Sichuan University from November 2007to July 2009were studied prospectively and random -ly assigned into Groups A and B, respectively. Both MSCT and CRP combinative assessments were made for preoperative evaluation in Group A, whereas only MSCT was performed preoperatively in Group B. Furthermore, the preoperative staging and prediction of opera-tive procedures were compared with postoperative pathologic staging and practical operative procedures, respectively. Results:Accord -ing to inclusion criteria, 120 colon cancer patients were included in Group A ( n = 60) and in Group B ( n = 60). The baseline character -istics of the two groups were statistically identical. For Group A, the accuracy of the preoperative T, N, M, and TNM staging were 71.7%,85.0%,98.3%, and 83.3%, respectively. For Group B, the corresponding rates were66.7%,65.0%,96.7%, and 65.0%, respec -tively. The difference in accuracy between the N and TNM staging between the two groups was observed statistically ( P = 0.011 and P = 0.022, respectively ). There was also a statistically significant difference in the accuracy of prediction of operative procedures be -tween Groups A and B ( 96.7% vs.86.7%,P = 0.048 ). Conclusion:The combinative assessment of colon cancer using MSCT and CRP could improve the accuracy of preoperative staging and the accurate prediction of surgical strategy in colon cancer.