免疫细胞浸润与肺癌关系研究进展

详细信息

Review of the Progress on the Relationship between Infiltration of Immune Cells and Lung Cancer

Department of Cardiothoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

摘要: 肺癌发病率高、死亡率高。而对于肺癌患者来说，其自身免疫系统在与肿瘤对抗过程中起着至关重要的作用，其中免疫细胞尤其是浸润于癌组织中的几种免疫细胞：肿瘤浸润淋巴细胞（TILS ）、肿瘤相关巨噬细胞（TAMS）、肿瘤浸润树突状细胞（TIDC）、肿瘤浸润NK细胞（TINK）扮演着重要角色。大量研究表明肿瘤浸润的各种免疫细胞与肺癌患者预后相关，并在抗肿瘤、肿瘤的免疫监视或免疫逃逸、促进肿瘤的发生发展和演进等各方面发挥着重要的作用。
- 肺癌 /
- 肿瘤免疫 /
- 免疫细胞
Abstract: Lung cancer has high morbidity and mortality rates. For patients with lung cancer the immune system ’s struggle with the cancer inevitably plays a crucial role in which several major immune cells, especially those infiltrating the cancer tissue such as tumor infiltrating lymphocytes (TILS), tumor associated macrophages (TAMS), tumor infiltrating den-dritic cells (TIDC), and tumor infiltrating NK cells (TINK), play an important role. A large number of studies have shown that the presence of tumor infiltrating immune cells is related to the prognosis of patients with lung cancer. These cells partici -pate in anti-tumor activities, immune surveillance and possibly immune system destruction of the tumor.
- Lung neoplasm /
- Tumor immunity /
- Immune cells