肝动脉灌注在结直肠癌肝转移治疗中的应用现状及前景

详细信息

Application of hepatic arterial infusion in the treatment of colorectal cancer liver metastasis

Department of Medical Oncology, Cancer Center, Sun Yat-Sen University, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China

摘要: 结直肠癌（colorectal cancer ，CRC ）是中国最常见的恶性肿瘤之一，肝转移是其主要的转移模式及治疗关键。相对于全身化疗，肝动脉灌注（hepatic arterial infusion，HAI）给药方式可使肝脏局部药物浓度升高，而外周血液中药物浓度较低，全身不良反应相对较低。HAI 化疗在肠癌肝转移的转化化疗、肝切除术后辅助化疗以及肠癌根治性切除术后的肝转移预防方面显示出一定的应用前景。本文就HAI 在肠癌肝转移的治疗现状及前景做一综述。
- 结直肠癌 /
- 肝转移 /
- 化学治疗 /
- 肝动脉灌注
Abstract: Colorectal cancer is one of the most common malignancies with a high risk of liver metastasis in China. Compared with systemic chemotherapy, hepatic arterial infusion (HAI) transports cytotoxic agents directly into the hepatic artery, leading to the persistent level of medicine in tumor cells and the relative lower systemic concentration. With advances in HAI, this technique has been successfully used not only as the pre- and post-operative chemotherapy for the resection of colorectal liver metastases, but also as an ad -juvant chemotherapy after the colorectal radical surgery to prevent the liver metastasis. This review discusses the application and per -spective of HAI in the treatment of colorectal cancer liver metastasis.
- colorectal cancer /
- liver metastasis /
- chemotherapy /
- hepatic arterial infusion

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