Erdheim Chester病多发骨侵犯1例

详细信息

图 1 全身骨显像

Figure 1. Whole-body bone scan

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图 2 骨梁间可见弥漫成片状分布的泡沫状组织细胞，符合富含组织细胞的肉芽肿性病变（HE×200）

Figure 2. There are diffuse distribution of foamy tissue cells in bone trabecula, in accordance with granulomatous lesions that are rich in tissue cells (HE×200)

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图 3 免疫组织化学显示CD68阳性，CD1a阴性（IHC×200）

Figure 3. The histiocytes are positive for CD68 and negative for CD1a in immunohistochemistry (IHC×200)

CD68 (+); B. CD1a (-)

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[1]	Campochiaro C, Tomelleri A, Cavalli G, et al. Erdheim-Chester disease[J]. Eur J Int Med, 2015, 26(4):223-229. DOI: 10.1016/j.ejim.2015.03.004
[2]	Haroche J, Arnaud L, Cohen-aubart F, et al. Erdheim-Chester Disease[J]. Curr Rheumatol Rep, 2014, 16(4):412. DOI: 10.1007/s11926-014-0412-0
[3]	Hervier B, Arnaud L, Charlotte F, et al. Treatment of Erdheim-Chester disease with long-term high-dose interferon-alpha[J]. Semin Arthritis Rheum, 2012, 41(6):907-913. DOI: 10.1016/j.semarthrit.2011.11.004
[4]	Cangi MG, Biavasco R, Cavalli G, et al. BRAFV600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease[J]. Ann Rheum Dis, 2015, 74(8):1596-1602. DOI: 10.1136/annrheumdis-2013-204924
[5]	Munoz J, Janku F, Cohen PR, et al. Erdheim-Chester disease: characteristics and management[J]. Mayo Clin proc, 2014, 89(7):985-996. DOI: 10.1016/j.mayocp.2014.01.023

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